Case 060

History/Physical

History/Physical:

48-year-old right-handed female.

Headache for six months.

Mild left leg weakness over four weeks.

Diagnosis: Atypical meningioma

Flowing oval monotonous nuclei in syncytial formations suggest a meningothelial lineage. Features of anaplasia including patternless growth, prominent nucleoli and elevated mitotic activity (>4 mitoses per 10 high power fields) are present.

Small pockets of necrosis (*) provide further evidence of anaplasia.

Vimentin (not shown) and epithelial membrane antigen are widely expressed.